The upcoming Bundesliga match between RB Leipzig and Hamburger SV is scheduled for September 13 at 20:30. Leipzig will host the match, and they come into it with a significant advantage in both home performance and historical head-to-head results against Hamburg.

Leipzig started the season with a solid 3-0 victory over Borussia M'Gladbach but has since suffered two consecutive defeats, losing 1-3 to Werder Bremen and 1-4 to Como in the Champions League. These recent losses have exposed vulnerabilities in their defense, as they conceded a total of seven goals in those matches. Coach Martin Demichelis is under pressure to improve the team's stability and performance, especially after the disappointing result against Como.

Historically, Leipzig has performed well against Hamburg, winning six out of their eight encounters, with one draw and only one loss. Currently, Hamburg is struggling at the bottom of the Bundesliga table, having lost both of their opening matches without scoring a goal, while conceding seven. Their lack of offensive production and defensive frailties make them a prime target for Leipzig, who will likely exploit these weaknesses.

For Leipzig, the absence of players like Ouedraogo, Romulo, Rocco Reitz, and Baumgartner due to injuries could impact their lineup, but they still possess a strong squad. Hamburg, on the other hand, is expected to field their optimal team as they seek to turn around their fortunes.

In summary, Leipzig's home advantage, historical dominance over Hamburg, and the latter's current struggles suggest that Leipzig is poised to secure three points in this matchup. The predicted scoreline is Leipzig 3, Hamburg 1.